High Cost Drug Manual (K&M Health Economy NTE Drugs Manual)

Click here to download the Kent and Medway Health Economy National Tariff Excluded Drugs Manual
Also known as the High Cost Drugs (HCD) Manual. Last updated: July 2020

 

The purpose of this manual is to describe the process for funding high cost drugs or devices excluded from the National Tariff payment system, (previously known as National Tariff Exclusions). These drugs or devices are only commissioned for those indications listed under the individual drug. With regard to items commissioned by CCG, drugs or devices may not be commissioned across every CCG.

Drugs or devices may not be commissioned across every CCG. Information on whether a CCG has commissioned a drug can be found in the “Commissioned By” box. Blueteq forms must be completed in all cases. Invoices will be refused for indications not listed within this manual.

The tables below contain a summary of the high cost drugs, for full details please see the entries within the manual.

High cost drugs are identified in this formulary by the  icon. The manual is linked directly to these drugs and can be accessed by clicking on the  icon to the right of the drug name.

Drug Name Indication Commissioner
Abacavir (Ziagen®) HIV in combination with other anti-retroviral drugs NHS England
Abacavir with Dolutegravir and Lamivudine (Triumeq®) HIV in combination with other anti-retroviral drugs NHS England
Abacavir and Lamivudine (Kivexa®) HIV in combination with other anti-retroviral drugs NHS England
Abaloparatide Male juvenile osteoporosis NHS England
Abatacept (Orencia®) Rheumatoid arthritis (1st line biologic ) CCGs
Abatacept (Orencia®) Rheumatoid Arthritis (2nd line biologic) CCGs
Abatacept (Orencia®) Juvenile Idiopathic arthritis (adult only)  CCGs
Abatacept (Orencia®) Juvenile idiopathic arthritis (paediatric) NHS England
Adalimumab (Humira®, Imraldi®, Amgevita®) Ankylosing Spondylitis and Axial Spondyloarthritis  CCGs
Adalimumab (Humira®, Imraldi®, Amgevita®) Chrohn’s Disease(1st and 2nd line biologic) CCGs
Adalimumab (Humira®, Imraldi®, Amgevita®) Psoriasis CCGs
Adalimumab (Humira®, Imraldi®, Amgevita®) Psoriatic Arthritis CCGs
Adalimumab (Humira®, Imraldi®, Amgevita®) Rheumatoid arthritis (1st line biologic ) CCGs
Adalimumab (Humira®, Imraldi®, Amgevita®) Rheumatoid Arthritis (2nd line biologic) CCGs
Adalimumab (Humira®, Imraldi®, Amgevita®) Juvenile idiopathic arthritis (adult) CCGs
Adalimumab (Humira®, Imraldi®, Amgevita®) Ulcerative Colitis (moderate to severe) CCGs
Adalimumab (Humira®, Imraldi®, Amgevita®) Juvenile idiopathic arthritis (paediatric) NHS England
Adalimumab (Humira®, Imraldi®, Amgevita®) Uveitis - Adult NHS England
Adalimumab (Humira®, Imraldi®, Amgevita®) Hidradenitis Suppurativa NHS England
Adalimumab (Humira®, Imraldi®, Amgevita®) Plaque psoriasis in children NHS England
Adalimumab (Humira®, Imraldi®, Amgevita®) Behcet's Syndrome NHS England
Adefovir (Hepsera®) Hepatitis B NHS England
Afatinib (Gilotrif®) Cancer NHS England
Aflibercept (Eylea®) Macular degeneration(wet age-related) CCGs
Aflibercept (Eylea®) Diabetic macular oedema CCGs
Aflibercept (Eylea®) Choroidal Neovascularisation CCGs
Aflibercept (Eylea®) Macular Oedema after BRVO(Branch Retinal Vein Occlusion) CCGs
Aflibercept (Eylea®) Macular Oedema secondary to central retinal vein occlusion CCGs
Aflibercept (Zaltrap®) Cancer NHS England
Agalsidase Alfa (Replagal®) Fabry’s Disease NHS England
Agalsidase Beta (Fabrazyme®) Fabry’s Disease NHS England
Albutropin Adult onset growth hormone deficiency NHS England
Aldesleukin (Proleukin®) Cancer NHS England
Alemtuzumab (MabCampath®) Multiple Sclerosis NHS England
Alemtuzumab (MabCampath®) Pre-transplant immunosuppression; Islet transplantation NHS England
Alemtuzumab (MabCampath®) Behcet's Syndrome NHS England
Alglucosidase Alfa (Myozyme®) Pompe disease NHS England
Alipogene Tiparvovec (Glybera®) Lipoprotein lipase deficiency NHS England
Alirocumab (Praluent®) Primary hypercholesterolaemia or mixed dyslipidaemia CCGs
Alirocumab (Praluent®) Primary heterozygous-familial hypercholesterolaemia CCGs
Alisporivir Hepatitis C NHS England
Alitretinoin (Toctino®) Eczema (chronic) CCGs
Alpha Mannosidase Recombinant Human Alpha Mannosidase Deficiency NHS England
Ambrisentan (Volbris®) Pulmonary arterial hypertension NHS England
Amifampridine phosphate (Firdapse®) Lambert-Easton Myasthenic Syndrome NHS England
Amikacin inhalation Fungal infection NHS England
Amikacin liposomal (Arikayce®) Cystic Fibrosis NHS England
Amphotericin liposomal (Abelcet®, AmBisome®) Fungal infection NHS England
Anabasum Scleroderma NHS England
Anakinra (Kineret®) Adult Onset Still's disease NHS England
Anakinra (kineret®) Juvenile Arthritis (paediatric) NHS England
Anakinra (kineret®) Periodic fevers and autoinflammatory conditions NHS England
Anakinra (kineret®) Cryopyrin Associated Periodic Syndrome (CAPS) NHS England
Anidulafungin (Ecalta®) Fungal infection NHS England
Anifrolumab SLE NHS England
Antilymphocyte globulin Aplastic Anaemia Organ Transplant NHS England
Antipseudomonas Aeruginosa IgY Cystic Fibrosis NHS England
Antithrombin III As per BCSH Guidelines for specialised indications NHS England
Antithymocyte immunoglobulin Aplastic Anaemia Organ Transplant NHS England
Apremilast (Otezla®) Psoriatic Arthritis CCGs
Apremilast (Otezla®) Moderate to severe plaque psoriasis CCGs
Arimoclomol Niemann-pick disease NHS England
Asfotase alpha (Strensiq®) Hypophosphatasia NHS England
Asunaprevir with Daclatasvir Hepatitis C NHS England
Atacicept Systemic lupus erythematosus (SLE) NHS England
Ataluren (Translarna®) Duchenne Muscular Dystrophy NHS England
Atazanavir (Reyataz®) HIV in combination with other anti-retroviral drugs NHS England
Atazanavir and Cobistat (Evotaz®) HIV in combination with other anti-retroviral drugs NHS England
Autologous serum eye drops Dry eye NHS England
Avacopan Anca-positive vasculitis NHS England
Avatrombopag (Doptelet®) Thrombocytopenia in people with chronic liver disease CCGs
Axitinib (Inlyta®) Cancer NHS England
Azacitidine  (Vidaza®) Cancer NHS England
Aztreonam lysine (Cayston®) Cystic Fibrosis NHS England
Aztreonam lysine (Cayston®) Cystic Fibrosis- continuous NHS England
Bardoxolone methyl Pulmonary arterial hypertension NHS England
Baricitinib (Olumiant®) Rheumatoid Arthritis CCGs
Basiliximab (Simulect®) Renal Transplant NHS England
Beclabuvir Hepatitis C NHS England
Bedaquiline Fumarate (Sirturo®) Extensively Drug Resistant TB NHS England
Bedaquiline Fumarate (Sirturo®) Multi drug resistant TB NHS England
Begelomab (Begedina®) Graft versus host disease NHS England
Belatacept (Nulojix®) Renal Transplant
NHS England
Belimumab (Benlysta®) Systemic lupus erythematosus (SLE) NHS England
Benralizumab (Fasenra®) Asthma NHS England
Beperminogene perplasmid Peripheral Vascular disease NHS England
Betaine (Cystadane®) Homocystinuria NHS England
Bevacizumab  (Avastin®) Choroidal neovascularisation (CNV) due to causes other than age-related macular degeneration (AMD) or pathological myopia (PM) CCGs
Bevacizumab  (Avastin®) Neurofibromatosis NHS England
Bevacizumab  (Avastin®) Cancer NHS England
Bictecravir (in combination with emtricitabine and Tenofovir alafenamide)  HIV in combination with other anti-retroviral drugs NHS England
Bimagrumab Inclusion Body Myositis NHS England
Biotin (Cerenday®) Multiple Sclerosis NHS England
Blisibimod  Systemic lupus erythematosus (SLE) NHS England
Bortezomib  (Velcade®) Organ rejection post kidney transplant NHS England
Bortezomib  (Velcade®) Cancer NHS England
Bosentan  (Tracleer®) Digital Ulcers NHS England
Bosentan  (Tracleer®) Pulmonary arterial hypertension NHS England
Bosutinib (Bosulif®) Cancer NHS England
Botulinum toxins A &B Achalasia CCGs
Botulinum toxins A &B Axillary hyperhidrosis CCGs
Botulinum toxins A &B Blepharospasm CCGs
Botulinum toxins A &B Chronic anal fissure CCGs
Botulinum toxins A &B Migraine CCGs
Botulinum toxins A &B Spasticity in neurological disorders CCGs
Botulinum toxins A &B Overactive bladder with symptoms of urinary incontinence, urgency and frequency CCGs
Botulinum toxins A &B (Xeomin only) Sialorrhoea in adults CCGs
Botulinum toxins A &B Spasticity in adults CCGs
Botulinum toxins A &B Urinary incontinence due to neurogenic detrusor over activity CCGs
Botulinum toxin Focal spasticity in children NHS England
Botulinum toxin Intravesical use in spinal cord injury NHS England
Brimapitide (Sonsuvi®) Acute Sensorineural hearing loss NHS England
Brincidofovir Cytomegalovirus NHS England
Brodalumab (Kyntheum®) Moderate to severe plaque psoriasis CCGs
Burosumab (Crysvita®) X linked Hypophosphataemia NHS England
C1 Esterase inhibitor (Berinert®, Cinryze®) Hereditary angioedema - acute treatment only NHS England
C1 Esterase inhibitor (Berinert®, Cinryze®) Hereditary angioedema – prophylactic treatment NHS England
C1 Esterase inhibitor (Berinert®, Cinryze®) Hereditary angioedema - prophylactic treatment in children (cinryze only) NHS England
Cabotegravir HIV in combination with other anti-retroviral drugs NHS England
Calcifediol Inborn Errors in Primary Bile Acid Synthesis NHS England
Canakinumab (Ilaris®) Cryopyrin Associated Periodic Fever Syndrome NHS England
Canakinumab (Ilaris®) Juvenile Arthritis (paediatric) NHS England
Cannabidiol (as epidiolex) Dravet Syndrome NHS England
Cannabidiol (as epidiolex) Lennox gestaut syndrome NHS England
Caplacizumab (Cablivi®) Thrombotic Thrombocytopenic pupura NHS England
Carglumic acid (Carbaglu®) Urea cycle disorders NHS England
Carnitine (Carnitor®) Carnitine deficiency NHS England
Caspofungin (Cancidas®) Fungal infection NHS England
Cenergermin (Oxervate®) Neurotrophic keratitis NHS England
Ceralifimod Multiple Sclerosis NHS England
Cerliponase alpha (Brineura®) Neuronal ceroid lipofuscinosis NHS England
Certolizumab pegol (Cimzia®) Rheumatoid Arthritis CCGs
Certolizumab pegol (Cimzia®) Moderate to severe plaque psoriasis CCGs
Certolizumab pegol (Cimzia®) Psoriatic Arthritis CCGs
Certolizumab pegol (Cimzia®) Ankylosing Spondylitis and Axial Spondyloarthritis  CCGs
Cetuximab (Erbitux®) Cancer NHS England
Chenodeoxycholic acid (Chenodeoxycholic acid sigma-tau®) Cerebrotendinous xanthomatosis (CTX) NHS England
Chenodeoxycholic acid (Chenodeoxycholic acid sigma-tau®) Primary biliary cirrhosis NHS England
Cholic acid Inborn Errors in Primary Bile Acid Synthesis NHS England
Cidofovir (Vistide®) Cytomegalovirus NHS England
Cinacalcet (Mimpara®) Hyperparathyroidism NHS England
Ciprofloxacin inhalation Cystic Fibrosis NHS England
Ciprofloxacin inhalation liposomal Cystic Fibrosis NHS England
Cladribine (Leustat®, Litak®) Multiple sclerosis NHS England
Cladribine (Leustat®, Litak®) Pulmonary Langerhans Histiocytosis NHS England
Clazakizumab Antibody medicated rejection NHS England
Cobistat (Tybost®) HIV in combination with other anti-retroviral drugs NHS England
Co-careldopa intestinal gel (Duodopa®) Parkinson’s disease NHS England
Colistimethate sodium (Colomycin®, Promixin®, Colobreathe®) Cystic Fibrosis NHS England
Collagenase clostridium hystoliticum (Xiapex®) Dupuytren’s contracture in patients with a palpable cord CCGs
Conestat alfa (Ruconest®) Hereditary angioedema - acute treatment only NHS England
Crizanlizumab Sickle Cell Disease NHS England
Crizotinib (Xalkori®) Cancer NHS England
Cyclic pyranopterin monophosphate Molybdenum cofactor deficiency NHS England
Cysteamine Bitartrate (mercaptamine) Nephropathic Cystinosis NHS England
Dabrafenib (Tafinlar®) Cancer NHS England
Darbepoetin alpha Dialysis - induced anaemia NHS England
Darunavir (Prezista®) HIV in combination with other anti-retroviral drugs NHS England
Darunavir with cobicistat (Rezolsta®) HIV in combination with other anti-retroviral drugs NHS England
Dasabvir (Exviera®) Hepatitis C NHS England
Dasatinib (Sprycel®) Cancer NHS England
Decitabine (Dacogen®) Cancer NHS England
Deferasirox (Exjade®) Iron chelation in thalassaemia and sickle cell NHS England
Deferiprone (Ferriprox®) Iron chelation in thalassaemia and sickle cell NHS England
Defibrotide (Defitelio®) Hepatic veno-occlusive disease NHS England
Delamanid (Deltyba®) Extensively drug resistant TB and multi drug resistant TB NHS England
Desferrioxamine (Desferal®) Iron chelation in thalassaemia and sickle cell NHS England
Dexamethasone intravitreal implant (Ozurdex®) Macular oedema (retinal vein occlusion) CCGs
Dexamethasone intravitreal implant (Ozurdex®) Non-infections uveitis CCGs
Dexamethasone intravitreal implant (Ozurdex®) Diabetic macular oedema CCGs
Dexrazoxane (Savene®1,Cardioxane®2) Anthracycline extravasation (Savene®) NHS England
Dexrazoxane (Savene®1,Cardioxane®2) Anthracycline Cardiotoxicity (Carioxane®) NHS England
Dibotermin alfa  (InductOs®) Complex spinal surgery NHS England
Dichlorphenamide Primary hypo and hyperkalaemic periodic paralysis NHS England
Didanosine  (Videx®) HIV in combination with other anti-retroviral drugs NHS England
Digoxin immune fab (DigiFab®) Digoxin toxicity This drug has not been formally commissioned, however due the nature of the indication it is considered that all CCGs would fund.
Dimethyl Fumarate (Skilarence) Moderate to severe plaque psoriasis CCGs
Dimethyl Fumarate (Tecfidera®) Multiple sclerosis NHS England
Diroximel fumarate Multiple sclerosis NHS England
Dolutegravir (Tivicay®) HIV in combination with other anti-retroviral drugs NHS England
Domagrozumab Duchenne Muscular Dystrophy NHS England
Doravirine (Pifeltro®) HIV in combination with other anti-retroviral drugs NHS England
Dornase alfa (Pulmozyme®) Cystic Fibrosis NHS England
Dornase alfa (Pulmozyme®) Primary Ciliary Dyskinesia NHS England
Drisapersen  Duchenne Muscular Dystrophy NHS England
Dupilumab (Dupixent®) Moderate to severe atopic dermatitis after topical treatments CCGs
Dupilumab (Dupixent®) Asthma NHS England
Ecallantide Hereditary angioedema - acute treatment only NHS England
Eculizumab (Soliris®) Atypical Haemolytic Uraemic Syndrom (aHUS) NHS England Central Team
Eculizumab (Soliris®) Paroxysmal Nocturnal Haemoglobinuria NHS England Central Team
Eculizumab (Soliris®) Organ Rejection post kidney transplant NHS England Central Team
Eculizumab (Soliris®) C3 Glomerulopathy (post-transplant) NHS England Central Team
Edasalonexent Duchenne Muscular Dystrophy NHS England
Edratide SLE NHS England
Efavirenz (Sustiva®) HIV in combination with other anti-retroviral drugs NHS England
Efraloctocog alph/efmoroctocog alfa/ Factor VIII FC fusion protein (Elocta®) Haemophilia A NHS England
Eftrenonacog Alfa (Alprolix®) Haemophilia B NHS England
Elbasvir+ Grazoprevir (Zepatier®) Hepatitis C NHS England
Eliglustat (Cerdelga®) Gaucher’s Disease NHS England
Elosulfase alfa (Vimizim®) Mucopolysaccharidosis IV Type A  NHS England
Eltrombopag (Revolade®) Thrombocytopenia purpura CCGs
Eltrombopag (Revolade®) Severe aplastic anaemia in adults CCGs
Eltrombopag (Revolade®) ITP in children NHS England
Elvitegravir (Vitekta®) HIV in combination with other anti-retroviral drugs NHS England
Elvucitabine HIV in combination with other anti-retroviral drugs NHS England
Emapalumab (Gamifant®) Haemophagocytic lymphohistiocytosis NHS England
Emicizumab (Hemlibra®) As per BCSH Guidelines for specialised indications NHS England
Emricasan Non- alchoholic steatohepatitis (NASH) Fibrosis NHS England
Emtricitabine (Emtriva®) HIV in combination with other anti-retroviral drugs NHS England
Emtricitabine with Tenofovir (Truvada®) HIV in combination with other anti-retroviral drugs NHS England
Emtricitabine with Tenofovir Alafenamide (Descovy®) HIV in combination with other anti-retroviral drugs NHS England
Emtricitabine + Rilpivirine + Tenofovir alafenamide (Odefsey®) HIV in combination with other anti-retroviral drugs NHS England
Emtricitabine + Tenofovir + Darunavir + Cobicistat (Symtuza®) HIV in combination with other anti-retroviral drugs NHS England
Emtricitabine + Tenofovir + Elvitegravir + Cobicistat (Genvoya®)  HIV in combination with other anti-retroviral drugs NHS England
Enfuvirtide (Fuzeon®) HIV in combination with other anti-retroviral drugs NHS England
Entecavir (Baraclude®) Hepatitis B NHS England
Enzalutamide (Xtandi®) Cancer NHS England
Epoetin Alpha, Beta, Theta and Zeta Dialysis - induced anaemia NHS England
Epoprostenol (Flolan®) Pulmonary Arterial Hypertension NHS England
Epratuzumab SLE NHS England
Eprodisate Amyloidosis NHS England
Eptotermin alfa (Opgenra®) Complex spinal surgery NHS England
Erlotinib Cancer NHS England
Etanercept (Enbrel®, Erelzi®, Benepali®) Adult Onset Still's disease CCGs
Etanercept (Enbrel®, Erelzi®, Benepali®) Ankylosing spondylitis CCGs
Etanercept (Enbrel®, Erelzi®, Benepali®) Psoriasis CCGs
Etanercept (Enbrel®, Erelzi®, Benepali®) Psoriatic Arthritis CCGs
Etanercept (Enbrel®, Erelzi®, Benepali®) Rheumatoid arthritis CCGs
Etanercept (Enbrel®, Erelzi®, Benepali®) Juvenile arthritis (adult) CCGs
Etanercept (Enbrel®, Erelzi®, Benepali®) Plaque psoriasis in children NHS England
Etanercept (Enbrel®, Erelzi®, Benepali®) Juvenile arthritis (paediatric) NHS England
Etelcalcetide (Parsabiv®) Hyperparathyroidism- dialysis patients only   
Eteplirsen (Exondys®) Duchenne Muscular Dystrophy NHS England
Etravirine (Intelence®) HIV in combination with other anti-retroviral drugs NHS England
Everolimus (Afinitor®) Cancer NHS England
Everolimus (Certican®) Preventing organ rejection in liver transplantation NHS England
Everolimus (Certican®) Preventing organ rejection in heart transplantation NHS England
Everolimus (Votubia®) Renal angiomyolipoma associated with Tubular sclerosis NHS England
Everolimus (Votubia®) Seizures associated with subependymal giant cell astrocytoma (sega) associated with tubular sclerosis  NHS England
Everolimus (Votubia®) Subependymal giant cell astrocytoma (SEGA) associated with Tubular sclerosis NHS England
Evinacumab Homozygous familial hypercholesterolemia NHS England
Evolocumab (Repatha SureClick®) Primary hypercholesterolaemia or mixed dyslipidaemia CCGs
Evolocumab (Repatha SureClick®) Primary heterozygous-familial hypercholesterolaemia CCGs
Evolocumab (Repatha SureClick®) Homozygous familial hypercholesterolemia NHS England
Ex-vivo expanded autologous human corneal epithelial cells containing stem cells 1 (Holoclar®) Treatment of adult patients with moderate to severe limbal stem-cell deficiency (LSCD), unilateral or bilateral, due to physical or chemical ocular burns. NHS England
Factor IX As per BCSH Guidelines NHS England
Factor VII As per BCSH Guidelines NHS England
Factor VIIa As per BCSH Guidelines NHS England
Factor VIII As per BCSH Guidelines NHS England
Factor VIII Fc fusion protein (Efmoroctocog alfa) (Elocta®) As per BCSH Guidelines NHS England
Factor VIII Inhibitor Bypassing Factor (FEIBA) As per BCSH Guidelines NHS England
Factor XIII As per BCSH Guidelines NHS England
Fampridine (Fampyra®) Multiple Sclerosis NHS England
Fedratinib (Inrebic®) Myelofibrosis NHS England
Fenfluramine (Fintepla®) Dravet Syndrome NHS England
Fibrinogen As per BCSH Guidelines for specialised indications NHS England
Fibroblast growth factor 1 gene therapy Somatostatin analogue NHS England
Fingolumod  (Gilenya®) Multiple Sclerosis NHS England
Fitusiran Haemophilia A and B  
Fluocinolone acetonide (Iluvien®) Non-infections uveitis CCGs
Fluocinolone acetonide (Iluvien®) Diabetic Macular Oedema CCGs
Fomepizole Ethylene glycol poisoning and Methanol poisoning CCGs
Forigerimod acetate (Lupuzor®) SLE NHS England
Fosamprenavir (Telzir®) HIV in combination with other anti-retroviral drugs NHS England
Foscarnet (Foscavir®) Cytomegalovirus NHS England
Fostemsavir HIV in combination with other anti-retroviral drugs NHS England
Fremanezumab (Ajovy®) Migraine CCGs
Galunisertib Cancer NHS England
Galsulfase (Naglazyme®) Mucopolysaccharidosis NHS England
Ganciclovir (Cymevene®) Cytomegalovirus NHS England
Ganetespib Cancer NHS England
Gefitinib (Iressa®)  Cancer NHS England
Gevokizumab Uveitis  NHS England
Givosiran Hepatic porphyria NHS England
Glatiramer acetate (Copaxone®) Multiple Sclerosis NHS England
Glecaprevir + Pibrentasvir Hepatitis C NHS England
Glucarpidase Methotrexate induced renal dysfunction NHS England
Glycerol Phenylbutyrate (Ravicti®) Urea Cycle Disorders NHS England
Golimumab (Simponi®) Ankylosing Spondylitis CCGs
Golimumab (Simponi®) Psoriatic arthritis CCGs
Golimumab (Simponi®) Rheumatoid arthritis CCGs
Golimumab (Simponi®) Ulcerative Colitis (moderate to severe) CCGs
Gosuranemab Supranuclear palsy NHS England
Granulocyte-macrophage colony-stimulating factor (Leukine® - Import) Antibody-positive pulmonary alveolar proteinosis NHS England
Guselkumab (Tremfya ®) Moderate to severe plaque psoriasis CCGs
HIV vaccine (Remune®) HIV Infection prophylaxis NHS England
Human alpha - 1 proteinase inhibitor  Emphysema NHS England
Human coagulation factor X Factor X deficiency NHS England
Human (haem) Arginate (Normosang®) Hepatic porphyria NHS England
Human heterologous liver cells Urea Cycle Disorders NHS England
Human parathyroid hormone-related protein analogue (Abaloparatide analogue) Male juvenile osteoporosis NHS England
Ibalizumab (Trogarzo®) HIV in combination with other anti-retroviral drugs NHS England
Icatibant (Firazyr®) Hereditary angioedema - acute treatment only NHS England
Icatibant (Firazyr®) Hereditary angioedema – prophylactic treatment NHS England
Idebenone (Raxone ®) Duchenne muscular dystrophy NHS England
Idursulfase (Elaprase®) Mucopolysaccharidosis NHS England
Iloprost (Ventavis®) Pulmonary Arterial Hypertension NHS England
Imatinib (Glivec®) Cancer NHS England
Imatinib (Glivec®) Graft versus host disease NHS England
Imetelstat Cancer NHS England
Imiglucerase (Cerezyme®) Gaucher’s Disease NHS England
Imlifidase (Idefirix ®) Transplant rejection prevention in HLA-sensitised patients NHS England
Indinavir (Crixivan®) HIV in combination with other anti-retroviral drugs NHS England
Inebilizumab Multiple Sclerosis NHS England
Infliximab (Inflectra, Remsima, Remicade, Flixabi®) Adult Onset Still's disease CCGs
Infliximab (Inflectra, Remsima, Remicade, Flixabi®) Ankylosing spondylitis CCGs
Infliximab (Inflectra, Remsima, Remicade, Flixabi®) Crohn’s disease CCGs
Infliximab (Inflectra, Remsima, Remicade, Flixabi®) Psoriasis CCGs
Infliximab (Inflectra, Remsima, Remicade, Flixabi®) Psoriatic Arthritis CCGs
Infliximab (Inflectra, Remsima, Remicade, Flixabi®) Rheumatoid arthritis CCGs
Infliximab (Inflectra, Remsima, Remicade, Flixabi®) Ulcerative Colitis (moderate to severe) CCGs
Infliximab (Inflectra, Remsima, Remicade, Flixabi®) Behcet's Syndrome NHS England
Infliximab (Inflectra, Remsima, Remicade, Flixabi®) Connective tissue disease - interstitial lung disease NHS England
Infliximab (Inflectra, Remsima, Remicade, Flixabi®) Crohn's disease in children NHS England
Infliximab (Inflectra, Remsima, Remicade, Flixabi®) Graft versus host disease NHS England
Infliximab (Inflectra, Remsima, Remicade, Flixabi®) Hidradenitis Suppurativa NHS England
Infliximab (Inflectra, Remsima, Remicade, Flixabi®) Juvenile arthritis NHS England
Infliximab (Inflectra, Remsima, Remicade, Flixabi®) Renal NHS England
Infliximab (Inflectra, Remsima, Remicade, Flixabi®) Pulmonary Sarcoidosis NHS England
Infliximab (Inflectra, Remsima, Remicade, Flixabi®) Sarcoidosis NHS England
Infliximab (Inflectra, Remsima, Remicade, Flixabi®) Uveitis  NHS England
Inotersen (Tegsedi®) Amyloidosis NHS England
Interferon Alfa (IntronA®, Roferon-A®) Hepatitis B and C NHS England
Interferon Alfa N3 Middle East Respiratory Syndrome NHS England
Interferon Beta (Avonex®, Rebif®, (beta-1a) Betaferon®, Extavia® (beta-1b) Multiple Sclerosis NHS England
Intravenous normal human immunoglobulins Multiple indications NHS England
Isavuconazole (Cresemba®) Fungal infection (licensed indications) NHS England
Ivacaftor (Kalydeco®) Cystic Fibrosis NHS England
Ixekizumab (Taltz®) Moderate to severe plaque psoriasis CCGs
Ixekizumab (Taltz®) Psoriatic Arthritis CCGs
Ixazomib (Ninlaro®) Amyloidosis NHS England
Ixazomib (Ninlaro®) Multiple Myeloma NHS England
Lamivudine (Epivir®1, Zeffix®2) HIV in combination with other anti-retroviral drugs NHS England
Lamivudine (Epivir®1, Zeffix®2) Hepatitis B NHS England
Lanadelumab (Takhzyro®) Hereditary Angioedema NHS England
Lanreotide (Somatuline® LA, Somatuline Autogel®) Cancer NHS England
Lanreotide (Somatuline® LA, Somatuline Autogel®) Acromegaly NHS England
Lanreotide (Somatuline® LA, Somatuline Autogel®) Congenital hyperinsulinism NHS England
Lanthanum Carbonate (Fosrenol®) Adult Renal dialysis only  NHS England
Lapatinib (Tyverb®) Cancer NHS England
Laquinimod (Nerventra®) Multiple Sclerosis NHS England
Laronidase (Aldurazyme®) Mucopolysaccharidosis NHS England
Lebrikizumab Asthma NHS England
Lenalidomide (Revlimid®) Cancer NHS England
Lenalidomide (Revlimid®) POEMS NHS England
Leronlimab HIV in combination with other anti-retroviral drugs NHS England
Letermovir (Prevymis®) Cytomegalovirus NHS England
Levofloxacin (inhaled) (Aeroquin® / Quinsair®) Cystic Fibrosis NHS England
Levoketoconazole (Normo-Cort®) Cushing's Disease NHS England
Lixivaptan  (Lixar®) Hyponatraemia and other endocrine uses NHS England
Lomitapide (Lojuxta®) Homozygous familial hypercholesterolemia NHS England
Lonafarinib Cancer NHS England
Lopinavir + Ritonavir (Kaletra®) HIV in combination with other anti-retroviral drugs NHS England
Lumacaftor with Ivacaftor (Orkambi®) Cystic Fibrosis NHS England
Lusutrombopag (Mulpleo ®) Thrombocytopenia in people with chronic liver disease CCGs
Luspatercept Cancer NHS England
Macimorelin Growth Failure NHS England
Macitentan (Opsumit®) Pulmonary Arterial Hypertension NHS England
Mannitol (Bronchitol®) Cystic Fibrosis NHS England
Maralixibat Alagille syndrome NHS England
Maraviroc (Celsentri®) Natalizumab induced PML NHS England
Maraviroc (Celsentri®) HIV in combination with other anti-retroviral drugs NHS England
Maribavir Cytomegalovirus NHS England
Masitinib (Masican®, Masiviera®) Pancreatic cancer/GIST NHS England
Mecasermin (Increlex®) Growth Failure NHS England
Mepolizumab (Nucala®) Asthma NHS England
Metreleptin (Myalepta®) Congenital leptin deficiency NHS England
Metreleptin (Myalepta®) Dyslipidaemia NHS England
Mexiletine (Namuscla®) Non dystrophic myotonia NHS England
Micafungin (Mycamine®) Fungal infection NHS England
Migalastat (Galafold®) Fabry’s Disease NHS England
Miglustat (Zavesca®) Gaucher's disease/Niemann- Pick NHS England
Momelotinib Cancer NHS England
Natalizumab (Tysabri®) Multiple Sclerosis NHS England
Nelfinavir (Viracept®) HIV in combination with other anti-retroviral drugs NHS England
Nevirapine (Viramune®) HIV in combination with other anti-retroviral drugs NHS England
Nilotinib (Tasigna®) Cancer NHS England
Nintedanib (Vargatef®)  Ovarian cancer NHS England
Nintedanib (Ofev®) Idiopathic pulmonary fibrosis NHS England
Nintedanib (Vargatef®)  Non-small-cell lung cancer NHS England
Nitazoxanide (Alinia®) Hepatitis C NHS England
Nitisinone (Orfadin®) Alkaptonuria NHS England
Nitisinone (Orfadin®) Tyrosinaemia NHS England
Nitric Oxide Pulmonary Arterial Hypertension NHS England
Nusinersen (Spinraza®) Spinal muscular atrophy NHS England
Obeticholic Acid (Ocaliva®) Primary biliary cirrhosis NHS England
Ocrelizumab (Ocrevus®) Primary progressive multiple sclerosis NHS England
Ocrelizumab (Ocrevus®) Multiple Sclerosis NHS England
Ocriplasmin (Jetrea®) Retinal disorders- Vitreomacular traction CCGs
Octocog alfa (NovoEight®) Haemophilia A NHS England
Octreolin (Mycapssa®) Acromegaly NHS England
Octreotide (Sandostatin®, SandostatinLar®) Cancer NHS England
Octreotide (Sandostatin®, SandostatinLar®) Acromegaly NHS England
Octreotide (Sandostatin®, SandostatinLar®) Congenital hyperinsulinism NHS England
Olesoxime Spinal muscular atrophy NHS England
Olipudase alfa Acid sphingomyelinase deficiency NHS England
Omalizumab (Xolair®) Severe Chronic Spontaneous Urticaria CCGs
Omalizumab (Xolair®) Asthma NHS England
Ombitasvir/Paritaprevir/ Ritonavir with Dasabuvir +/- Ribavirin (Viekirax®) Hepatitis C NHS England
Ozanimod Multiple Sclerosis NHS England
Pacritinib (Epjevy®) Myelofibrosis NHS England
Palivizumab (Synagis®) Respiratory Syncytial Virus Prophylaxis NHS England
Palovarotene Fybrodysplasia ossificans progressiva NHS England
Para- aminosalicylic acid (GranuPAS®) Tuberculosis NHS England
Parathyroid Hormone (Preotact®) Osteoporosis CCGs
Parathyroid Hormone (Preotact®) Specialist endocrinology conditions NHS England
Parenteral Nutrition (Home use) Intestinal Failure NHS England
Parenteral Nutrition (Inpatient use) Intestinal Failure; inadequate/unsafe enteral feeding NHS England
Paricalcitol (Zemplar®) Hyperparathyroidism NHS England
Paritaprevir Hepatitis C NHS England
Pasireotide (Signifor®) Acromegaly NHS England
Pasireotide (Signifor®) Cushing's Disease NHS England
Patisiran (Onpattro) Amyloidosis NHS England
Pazopanib (Votrient®) Cancer NHS England
Peginterferon alfa (Pegasys®, ViraferonPeg®) Hepatitis B and C NHS England
Peginterferon beta-1A (Plegridy®) Multiple Sclerosis NHS England
Pegunigalsidase alfa Fabry’s Disease NHS England
Pegvaliase (Palynziq®) Phenylketonuria NHS England
Pegvisomant  (Somavert®) Acromegaly NHS England
Pembrolizumab (Keytruda®) Cancer indications NHS England
Pembrolizumab (Keytruda®) Drug resistant gestational trophoblastic neoplasia NHS England
Pibrentasvir Hepatitis C NHS England
Pirfenidone (Esbriet®) Idiopathic pulmonary fibrosis NHS England
Plerixafor (Mozobil®) Stem cell mobilisation NHS England
Pomalidomide (Imnnovid®) Cancer NHS England
Pomalidomide (Imnnovid®) Myelofibrosis NHS England
Ponatinib (Iclusig®) Cancer NHS England
Ponesimod Multiple Sclerosis NHS England
Posaconazole (Noxafil®) Fungal Infection NHS England
Pretomanid Multi drug resistant TB NHS England
Protein C As per BCSH Guidelines for specialised indications NHS England
Prothrombin complex As per BCSH Guidelines for specialised indications NHS England
Raltegravir  (Isentress®) HIV in combination with other anti-retroviral drugs NHS England
Ranibizumab (Lucentis®) Macular oedema (Retinal vein occlusion) CCGs
Ranibizumab (Lucentis®) Diabetic Macular Oedema CCGs
Ranibizumab (Lucentis®) Macular degeneration(wet age-related) CCGs
Ranibizumab (Lucentis®) Choroidal neovascularisation (CNV) associated with pathological myopia CCGs
Rasburicase (Fasturtec®) Hyperuricaemia NHS England
Ravulizumab  Paroxysmal Nocturnal Haemoglobinuria NHS England
Raxibacumab (ABthrax®) Inhaled anthrax NHS England
Refanalin Prevention of delayed graft function NHS England
Regorafenib (Stivarga®) Cancer NHS England
Reparixin Prevention of delayed graft function NHS England
Reslizumab (Cinquil®) Asthma NHS England
Rilpivirine (Edurant®) HIV in combination with other anti-retroviral drugs NHS England
Rimeporide Duchenne muscular dystrophy NHS England
Riociguat (Adempas®) Pulmonary Arterial Hypertension (CTEPH) NHS England
Riociguat (Adempas®) Pulmonary Arterial Hypertension NHS England
Risankizumab (Skyrizi®) Moderate to severe plaque psoriasis CCGS
Risdiplam Spinal muscular atrophy NHS England
Ritonavir  (Norvir®) HIV in combination with other anti-retroviral drugs NHS England
Rituximab (Mabthera®) Rheumatoid Arthritis CCGs
Rituximab (Mabthera®) Immune (idiopathic) thrombocytopenic purpura (ITP) CCGs 
Rituximab (Mabthera®) ABO-incompatible kidney transplants NHS England
Rituximab (Mabthera®) Acquired Haemophilia NHS England
Rituximab (Mabthera®) ANCA-positive vasculitis NHS England
Rituximab (Mabthera®) Anti-Inmdar autoimmune encephalitis NHS England
Rituximab (Mabthera®) Chronic inflammatory demyelinating polyneuropathy NHS England
Rituximab (Mabthera®) Connective tissue disease - interstitial lung disease NHS England
Rituximab (Mabthera®) Dermatomyositis and Polymyositis (Adults) NHS England
Rituximab (Mabthera®) Graft versus host disease NHS England
Rituximab (Mabthera®) Juvenile Arthritis (paediatric) NHS England
Rituximab (Mabthera®) Membranous Nepropathy NHS England
Rituximab (Mabthera®) Myasthenia Gravis NHS England
Rituximab (Mabthera®) Myositis NHS England
Rituximab (Mabthera®) Nephritis NHS England
Rituximab (Mabthera®) Neuromyelitis optica NHS England
Rituximab (Mabthera®) Pemphigus vulgaris NHS England
Rituximab (Mabthera®) Primary Sjogren's Syndrome (PSS) NHS England
Rituximab (Mabthera®) Systemic lupus erythematosus (SLE) NHS England
Rituximab (Mabthera®) Steroid sensitive nephrotic syndrome NHS England
Rituximab (Mabthera®) Immunoglobulin G4 Related Disease NHS England
Rituximab (Mabthera®) Focal segmental glomerulosclerosis NHS England
Rituximab IV Cancer NHS England
Rituximab S/C Cancer NHS England
Rivipansel sodium Hepatic veno-occlusive disease NHS England
Rivipansel sodium Sickle Cell Disease NHS England
Romiplostim (Nplate®) Thrombocytopenia purpura CCGs
Romiplostim (Nplate®) ITP in children NHS England
Ropeginterferon alfa-2b Hepatitis C NHS England
Roxadustat Dialysis - induced anaemia NHS England
Rurioctocog alfa pegol (Adynovate®) Haemophilia A NHS England
Ruzasvir Hepatitis C NHS England
Ruxolitinib  (Jakavi®)  Cancer NHS England
Sacrosidase (Sucraid®) Congenital sucrase isomaltase deficiency NHS England
Sapropterin (Kuvan®) Maternal phenylketonuria NHS England
Sapropterin (Kuvan®) Adults and Children with Phenylketonuria NHS England
Saquinavir (Invirase®) HIV in combination with other anti-retroviral drugs NHS England
Sarilumab (Kevzara®) Rheumatoid Arthritis CCGs
Satralizumab Neuromyelitis optica NHS England
Sebelipase alfa (Kanuma®) Lysosomal acid lipase deficiency NHS England
Secukinumab (Cosentyx®) Ankylosing spondylitis CCGs
Secukinumab (Cosentyx®) Moderate to severe plaque psoriasis CCGs
Secukinumab (Cosentyx®) Psoriatic Arthritis CCGs
Selexipag (Uptravi®) Pulmonary hypertension NHS England
Setrusumab Osteogenesis imperfecta NHS England
Sevelamer (Renvela®) Adult Renal dialysis only  NHS England
Siponimod (Mayzent®) Multiple Sclerosis NHS England
Sirolimus (Rapamune®) Transplant immunosuppression only  NHS England
Sodium Oxybate (Xyrem®) Narcolepsy - paediatric services only NHS England
Sodium Phenylbutyrate (Ammonaps®) Urea cycle disorders NHS England
Sofosbuvir/Ledipasvir+/- Ribavirin (Harvoni®) Hepatitis C NHS England
Sofosbuvir/Peginterferon + Ribavirin Hepatitis C NHS England
Sofosbuvir/Velpatasvir (Epclusa®) Hepatitis C NHS England
Somatropin (Genotropin®, Humatrope®, Norditropin®, NutropinAq®, Omnitrope®, Saizen®, Zomacton®) Growth Failure/ Hormone deficiency  CCGs
Sorafenib (Nexavar®) Cancer NHS England
Stavudine (Zerit®) HIV in combination with other anti-retroviral drugs NHS England
Subcutaneous Human normal immunoglobulins Multiple indications NHS England
Sucroferric oxyhydroxide (Velphoro®) Adult Renal dialysis only  NHS England
Sunitinib (Sutent®) Cancer NHS England
Sutimlimab Primary cold agglutinin disease NHS England
Tabalumab SLE NHS England
Tafamandis Amyloidosis NHS England
Taliglucerase alfa Gaucher’s Disease NHS England
Taribavirin Hepatitis C NHS England
Teduglutide (Revestive®) Short Bowel syndrome NHS England
Telbivudine (Sebivo®) Hepatitis B NHS England
Temsirolimus Cancer NHS England
Tenofovir (Viread®) HIV in combination with other anti-retroviral drugs NHS England
Tenofovir (Viread®) Hepatitis B +/- other anti-retroviral drugs NHS England
Tenofovir Alafenamide (Vemlidy®) Hepatitis B NHS England
Tenofovir Alafenamide (Vemlidy®) HIV in combination with other anti-retroviral drugs NHS England
Tenofovir Alafenamide + Cobicistat + Elvitegravir + Emtricitabine (Genvoya®) HIV in combination with other anti-retroviral drugs NHS England
Tenofovir Disproxil + Cobicistat + Elvitegravir + Emtricitabine (Stribild®)  HIV in combination with other anti-retroviral drugs NHS England
Tenofovir with Emtricitabine and Efavirenz (Atripla®) HIV in combination with other anti-retroviral drugs NHS England
Tenofovir with Emtricitabine and rilpivirine (Eviplera®) HIV in combination with other anti-retroviral drugs NHS England
Teprasiren Prevention of delayed graft function NHS England
Teprotumumab Graves orbitopathy NHS England
Teriflunomide (Aubagio®) Multiple Sclerosis NHS England
Teriparatide (Forsteo®, Terrosa®, Movymia®) Osteoporosis CCGs
Teriparatide  (Forsteo®, Terrosa®, Movymia®) Osteogenesis imperfecta NHS England
Teriparatide  (Forsteo®, Terrosa®, Movymia®) Male juvenile osteoporosis NHS England
Tetrahydrobiopterin Phenylketonuria NHS England
Tezacaftor with ivacaftor Cystic Fibrosis NHS England
Tezepelumab Asthma NHS England
Thalidomide (Thalidomide Celegene®) Cancer NHS England
Thrombomodulin, recombinant human Pseudoaneurysm NHS England
Tildrakizumab (Ilumetri®) Moderate to severe plaque psoriasis CCGs
Tipranavir (Aptivus®) HIV in combination with other anti-retroviral drugs NHS England
Tobramycin (for nebulisation) (Tobi®, Bramitob®) Cystic Fibrosis NHS England
Tocilizumab (RoActemra®) Rheumatoid Arthritis CCGs
Tocilizumab (RoActemra®) Juvenile arthritis (adult) CCGs
Tocilizumab (RoActemra®) Juvenile arthritis (paediatric) NHS England
Tocilizumab (RoActemra®) Adult Onset Still's disease NHS England
Tocilizumab (RoActemra®) Takayasu arteritis NHS England
Tocilizumab (RoActemra®) Giant cell arteritis NHS England
Tocilizumab (RoActemra®) Cytokine release syndrome NHS England
Tofacitinib (Xeljanz®) Rheumatoid Arthritis CCGs
Tofacitinib (Xeljanz®) Psoriatic Arthritis CCGs
Tofacitinib (Xeljanz®) Ulcerative Colitis (moderate to severe) CCGs
Tolvaptan (Samsca®) Autosomal dominant polycystic kidney disease CCGs
Tolvaptan (Samsca®) Hyponatraemia in cancer NHS England
Tralokinumab Asthma NHS England
Trenonacog alpha Haemophilia B NHS England
Treprostinil Diethanolamine Pulmonary arterial hypertension NHS England
Treprostinil Sodium  (Tyvaso®) Pulmonary arterial hypertension NHS England
Trientine  Wilson's Disease NHS England
Triheptanoin  Pyruvate carboxylase deficiency NHS England
Uprifosbuvir Hepatitis C NHS England
Ustekinumab (Stelara®) Psoriasis CCGs
Ustekinumab (Stelara®) Psoriatic Arthritis CCGs
Ustekinumab (Stelara®) Crohn’s disease CCGs
Ustekinumab (Stelara®) Ulcerative Colitis (moderate to severe) CCGs
Ustekinumab (Stelara®) Plaque psoriasis in children NHS England
Vadadustat Dialysis - induced anaemia NHS England
Valganciclovir (Valcyte®) Cytomegalovirus NHS England
Vandetanib (Caprelsa®) Thyroid cancer NHS England
Vatiquinone Friedreichs ataxia NHS England
Vedolizumab (Entyvio®) Ulcerative Colitis (moderate to severe) CCGs
Vedolizumab (Entyvio®) Crohn’s disease CCGs
Velaglucerase alfa (VPRIV®) Gaucher’s Disease NHS England
Velcalcetide Hyperparathyroidism NHS England
Velmanase alfa (Lamzede®) Alpha Mannosidase Deficiency NHS England
Vemurafenib (Zelboraf®) Melanoma NHS England
Verteporfin (Visudyne®) Central serous chorioretinopathy CCGs
Verteporfin (Visudyne®) Polypoidal choroidal vasculopathy CCGs
Vestronidase alfa (Mepsevii®) Mucopolysaccharidosis VIII NHS England
Volanesorsen (Waylivra®) Familial Chylomicronemia syndrome NHS England
Vonicog alfa (Veyvondi®) Von Willebrand Deficiency NHS England
Von willebrand factor, recombinant (Vonvendi®) Von willebrand deficiency NHS England
Voretigene Neparvovec (Luxturna®) Inherited retinal disorders NHS England
Voriconazole (Vfend®) Fungal infection NHS England
Voriconazole (Vfend®) Chronic pulmonary aspergillosis NHS England
Voxelotor Sickle Cell Disease NHS England
VX-210 (Cethrin®) Spinal Cord injury NHS England
Ziconotide (Prialt®) Intrathecal analgesia NHS England
Zidovudine (Retrovir®) HIV in combination with other anti-retroviral drugs NHS England
Zidovudine with Lamivudine (Combivir®) HIV in combination with other anti-retroviral drugs NHS England
Zidovudine with Lamivudine and Abacavir (Trizivir®) HIV in combination with other anti-retroviral drugs NHS England

 

Not to be prescribed

Drug Name Indication Commissioner
Cysteamine hydrochloride (mercaptamine)    
Daclizumab (Zinbryta®) Multiple sclerosis NHS England
Damoctocog alfa pegol Haemophilia A  
Filibuvir Hepatitis C NHS England
Fostamatinib Disodium (Tavalisse®)    
Gantenerumab Alzheimer’s Disease  
Glycerol Phenylbutyrate (Ravicti®) Urea Cycle Disorders NHS England
Ketorolac with Phenylephrine (Omidria®) Intraocular lens replacement surgery  
Lampalizumab    
Pegaptanib (Macugen®) Macular degeneration NHS England
Porcine factor    
Sialic acid Myopathy NHS England
Siltuximab (Sylvant®)    
Tanezumab    
Vancomycin (via unique delivery system)